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Despite the complexities and the many factors involved in diseases of iron metabolism and iron toxicity, the identification of the mechanisms involved, and the use of appropriate diagnostic criteria could provide efficient targeted therapies and the complete elimination of iron toxicity, as shown in the case of the transition of thalassaemia from a fatal to a chronic disease [39,88,295,296,297,298]

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Regardless of its source of production, ascorbate is distributed to the tissues via the circulation, 9 with active transport across cell membranes and into intracellular compartments via the sodium-dependent vitamin C transporters SVCT1 and SVCT2, encoded by SLC23A1 and SLC23A2 , respectively